政雀通

腺病毒基因组学、流行病学、新载体、抗病毒药物、疫苗：

（1）利用新策略开发有效特异的抗腺病毒药物和疫苗、建立优化动物感染和致病模型。

（2）鉴定发现新的腺病毒种类、腺病毒传播机制、腺病毒基因组重组机制研究

（3）动物腺病毒的跨种传播机制、腺病毒种属特异性机制的研究；

（4）新型猴腺病毒载体的研发；

（5）腺病毒为载体的新冠病毒疫苗研究

My research interests are the genomics, epidemiology, novel vectors, antivirals and vaccines for human adenoviruses (AdVs) and other respiratory viruses, such as novel coronaviruses, influenza viruses, etc.

(1) Recently, more and more human acute respiratory disease outbreaks caused by AdV have emerged in China schools and military. We are developing effective antiviral drugs and vaccine candidates using new strategies and optimal animal models.

(2) Analysis of whole-genome sequences for these emergent AdVs and identification of the homologous recombination and transmission mechanism in AdV evolution.

(3) The potential cross-species transmission (CST) of animal AdVs is a threat to human health. The explorer of CST of AdVs in simians provides a scientific basis for the prevention and control of CST

(4) Developemt of the novel AdV vectors.

(5) Development of novel adenovirus vectored coronavirus vaccines and replication-deficient coronavirus vaccines.